The revolutionary possibility of clean, safe, and reliable energy easily accessible to all has been thought to be impossible. Who would have imagined that harnessing power densities comparable in magnitude to conventional fission or fusion but producing no toxic emissions or dangerous radiation would be plausible? Throughout the 20th century, scientists have observed anomalous heat that could not be explained by chemistry alone. Until recent years, reproducing this phenomenon has been difficult but the multiple developments in quantum science, nanomaterials, and advanced manufacturing suggest a new type of nuclear energy may be at hand.